Vlastimir-Djuza Stojiljkovic was born in Razanj near Krusevac into a teacher's family. After graduating from Krusevac Grammar School he registered at the School of Mining in Belgrade, but after three semesters he entered Drama Academy in Belgrade and graduated from it in professor Mata Milosevic's class (1948-1952). His first stage appearance was as a schoolboy in "Krusevac County National Theatre", in 1946. After acting studies, in 1952 he becomes a member of Belgrade Drama Theatre in Belgrade where he worked until 1968 when he moved to Atelje 212 to perform for ten seasons.

In 1979 he returned to Belgrade Drama Theatre and stayed there until 1985 when he returned to Atelje 212 and remained until retirement in 1994. During his fifty-year long and fruitful career, Stojiljkovic realized more than 150 theater roles. He also acted in 16 films and the greatest role in Nights and Days (1959)), more than 40 TV dramas and 20 TV series. The character Rodja Petrovic in Novak Novak's TV serial Pozoriste u kuci (1972) is considered to be not only one of the greatest achievements of this actor, but also of the complete art production of TV Belgrade.