Humeyra began her career as a musician during 1970s, recognized by her songs including Kordugum, Sessiz Gemi, Otuzbes Yas. Later, outside the popular line, she recorded albums such asTutkulardan İntihar and Beyhude. She did theatre, acted in television and cinema.She also took part in Ferhan Şensoy’s Ortaoyuncular team in 1985, in a play called Icinden Tramvay Gecen Sarkı. In 1986, she won Best Supporting Actress Award for her role in Asiye Nasıl Kurtulur? in Antalya Golden Orange Film Festival. In 2007, she received the Isık Sacan Apollon traditional honor award in 10. Istanbul International Film History Gathering.